Smoking and FoodNB: For the sake of simplicity "cigarette(s)" or "cigarette smoke" is used, although similar conclusions can be drawn for other tobacco-based products. Introduction Cigarettes and prepared (non-raw, or heated) food have more in common than most people know. Prepared food, like cigarettes, contains physically addictive beta-carbolines, addictive additives, and also mutagenic heterocyclic amines (see below). People who quit smoking often compensate the loss of addictive substances from the cigarettes with those in prepared food, which explains why so many overeat, and thus gain weight after quitting. Addictive additives Cow's milk protein includes addictive opioid peptides (1). This addictive property is the reason it's added to many food products. Formula milk is one of these products, that makes children addicted to cow's milk protein at a very young and vulnerable age, ensuring a future market for milk protein containing products. Third world countries are an increasing market for formula milk, so food companies are pressing women in those countries to give their babies formula milk instead of mother's milk. Of course the huge quantities of powdered milk in humanitarian food aid supplies also help. Wheat protein also contains very potent opioid peptides (2), sometimes even 100 times more powerful than morphine. (3) Like milk protein, wheat (protein) is used in, or added to many food products as an effective addictive compound. Adding both milk and wheat protein is even more effective. By heating wheat and milk proteins, they are becoming even more resistant to being broken down by our digestive enzymes. Such slightly (chemically) altered opioid peptides can be extremely hard to decompose, either due to their unnatural composition, or because they directly inhibit digestive enzyme activity. (4) Heating protein (together with carbohydrates) originates new substances, HeteroCyclic Amines (HCAs), which can have mutagenic and carcinogenic properties. Some of these HCAs are beta-carbolines, and many of these beta-carbolines also inhibit enzymes that decompose opioid peptides. (5) Beta-carbolines are also addictive, directly (6) or indirectly. (7) Taste enhancers for example are concentrated dehydrated proteins, containing lots of beta-carbolines. They therefore don't exactly 'enhance taste' but feed addiction, by influencing neurotransmitter receptors. (8) To create very effective 'taste enhancers', some protein (preferably wheat or milk protein) is mixed with sugars, and then heated thoroughly. Food manufacturers of course know all this. Years ago, a Nestlé spokesman declared that "food manufacturers could use this information to sell more food". (9) Mutagenic and carcinogenic compounds
Mutagenic heterocyclic amine concentration in prepared food can be much higher than in cigarette smoke. For example: 100 grams (3.5 oz.) of prepared meat contains as much of the mutagenic compound AalphaC as the smoke of 812 cigarettes, and as much of the even more mutagenic MeAalphaC as the smoke of 1,050 cigarettes! (21) Conclusion © 2000-2009 Copyright Artists Cooperative Groove Union U.A.
Abstracts of most sources can be found at the National Library of Medicine
(1) Teschemacher, H. et al, Milk protein-derived opioid receptor ligands. Biopolymers. 1997 / 43 (2) / 99-117., Teschemacher, H. et al, Chemical characterization and opioid activity of an exorphin isolated from in vivo digests of casein. FEBS Lett. 1986 / 196 (2) / 223-227., Chang, K.-J. et al, Isolation of a specific mu-opiate receptor peptide, morphiceptin, from an enzymatic digest of milk proteins. J. Biol. Chem. 1985 / 260 (17) / pag. 9706-9712. (2) Fukudome, S. et al, Gluten exorphin C: a novel opioid peptide derived from wheat gluten. FEBS Lett. 1993 / 316 (1) / 17-19. (3) Max, B., This and that : an artefactual alkaloid and its peptide analogs. Trends Pharmacol. Sci. 1992 / 13 (9) / 341-345. (4) Dutta, A.S., Small Peptides, Chemistry, Biology and Clinical Studies, Amsterdam 1993 / 550-556, 560. (5) Coletti-Previero, M.A. et al, Beta-carboline and diazepam effect on the degradation of enkephalin by the human blood aminopeptidase. Biosci. Rep. 1983 / 3 (1) / 87-92. (6) Loscher, W. et al, Withdrawal precipation by benzodiazepine receptor antagonists in dogs chronically treated with diazepam or the novel anxiolytic and anticonvulsant beta-carboline abecarnil. Naunyn Schmiedebergs Arch. Pharmacol. 1992 / 345 (4) / 452-460. , Little, H.J. et al, The benzodiazepines : anxiolytic and withdrawal effects. Neuropeptides 1991 / 19 / suppl. 11-14., Eisenberg, R.M. et al, Effects of beta-carboline-ethyl ester on plasma corticosterone -- a parallel with antagonist-precipated diazepam withdrawal. Life Sci. 1989 / 44 (20) / 1457-1466. (7) De Boer, S.F. et al, Common mechanisms underlying the proconflict effects of corticotropin, a benzodiazepine inverse agonist and electric foot shock. J. Pharmacol. Exp. Ther. 1992 / 262 (1) / 335-342. , Maiewski, S.F. et al, Evidence that a benzodiazepine receptor mechanism regulates the secretion of pituitary beta-endorphin in rats. Endocrinology 1985 / 117 (2) / 474-480. (8) Aoshima, H. and Y. Tenpaku: Modulation of GABA receptors expressed in Xenopus oocytes by 13-L-Hydroxylinoleic acid and food additives. Bioscience, Biotechnology and Biochemistry 1997 / 61 / 2051-2057. Aoshima, H., Effects of alcohols and food additives on glutamate receptors expressed in Xenopus oocytes: Specifity in the inhibition of the receptors. Bioscience, Biotechnology and Biochemistry 1996 / 60 / 434-438. Aoshima, H. et al, Effects of aliphatic alcohols and food additives on nicotinic acetylcholin receptors in Xenopus oocytes. Bioscience, Biotechnology and Biochemistry 1994 / 58 / 1776-1779. (9) Witherly, S. from Nestlé in: Solms, J. et al, Food Acceptance and Nutrition. London 1987 / 403. (10) Totsuka, Y. et al, Structural determination of a mutagenic aminophenylnorharman produced by the co-mutagen norharman with aniline. Carcinogenesis 1998 / 19 (11) / 1995-2000., Wakabayashi, K. et al, Human exposure to mutagenic/carcinogenic heterocyclic amines and comutagenic beta-carbolines. Mutat. Res. 1997 / 376 (1-2) / 253-259. (11) Solyakov, A. et al, Heterocyclic amines in process flavours, process flavour ingredients, bouillon concentrates and a pan residue. Food Chem. Toxicol. 1999 / 37 (1) / 1-11., Skog, K. et al, Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectometry. J. Chromatogr. A. 1998 / 803 (1-2) / 227-233., Stavric, B. et al, Mutagenic heterocyclic aromatic amines (HAA's) in 'processed food flavour' samples. Food Chem. Toxicol. 1997 / 35 (2) / 185-197., Wakabayashi, K. et al, Human exposure to mutagenic / carcinogenic heterocyclic amines and comutagenic beta-carbolines. Mutat. Res. 1997 / 376 (1-2) / 253-259., Galceran, M.T. et al, Determination of heterocyclic amines by pneumatically assisted electrospray liquid chromatography-mass spectometry. J. Chromatogr. A. 1996 / 730 (1-2) / 185-194. , Gross, G.A. et al, Heterocyclic aromatic amine formation in grilled bacon, beef and fish and in grilled scrapings. Carcinogenesis 1993 / 14 (11) / 2313-2318., Sugimura, T. et al, Mutagenic factors in cooked foods. Crit. Rev. Toxicol. 1979 / 6 (3) / 189-209. (12) Wakabayashi, K. et al, Identification of new mutagenic heterocyclic amines and quantification heterocyclic amines. Princess Takamatsu Symp. 1995 / 23 / 39-49. (13) Ashida, H. et al, Tryptophan pyrolysis products, Trp-P-1 and Trp-P-2 induce apoptosis in primary cultured rat hepatocytes. Biosci. Biotechnol. Biochem. 1998 / 62 (11) / 2283-2287. , Sasaki, Y.F. et al, In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in a multiple organ study in the mouse. Mutat. Res. 1997 / 395 (1) / 57-73., Sugimura,T. et al, Mutagens in food. Journal of Agriculture and Food Chemistry 1995 / 43 / 404-414., Manabe, S. et al, Carcinogenic tryptophan pyrolysis products in the environment. J. Toxicol. Sci. 1991 / 16 (suoppl.1) / 63-72. (14) De Flora, S. et al, Modulation of the potency of promutagens and direct acting mutagens in bacteria by inhibitors of the multidrug resistance mechanism. Mutagenesis 1997 / 12 (6) / 431-435. (15) Skog, K. et al, Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectometry. J. Chromatogr. A. 1998 / 803 (1-2) / 227-233. , Ashida, H. et al, Tryptophan pyrolysis products, Trp-P-1 and Trp-P-2 induce apoptosis in primary cultured rat hepatocytes. Biosci. Biotechnol. Biochem. 1998 / 62 (11) / 2283-2287., Sasaki, Y.F. et al, In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in a multiple organ study in the mouse. Mutat. Res. 1997 / 395 (1) / 57-73. , Galceran, M.T. et al, Determination of heterocyclic amines by pneumatically assisted electrospray liquid chromatography-mass spectometry. J. Chromatogr. A. 1996 / 730 (1-2) / 185-194., Yamaguchi, K. et al, Presence of 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole in broiled beef. Gann. 1980 / 71 (5) / 745-746. , Yamaizumi, Z. et al, Detection of potent mutagens, Trp-P-1 and Trp-P-2 in broiled fish. Cancer Lett. 1980 / 9 (2) / 75-83., Sugimura, T. et al, Mutagenic factors in cooked foods. Crit. Rev. Toxicol. 1979 / 6 (3) / 189-209. (16) Bartsch, H. et al, Black (air-cured) and blond (flue-cured) tobacco cancer risk. 4 Molecular dosimetry studies implicate aromatic amines as bladder carcinogenesis. Eur. J. Cancer 1993 / 29A (8) / 1199-1207. (17) Hammons, G.J. et al, Effects of chemoprotective agents on the metabolic activation of the carcinogenic arylamines PhIP and 4-aminobiphenyl in human and rat liver microsomes. Nutr. Cancer 199 / 33 (1) / 46-52. (18) Sasaki, Y.F. et al, Colon specific genotoxicity of heterocyclic amines detected by themodified alkaline single cell gel electrophoresis assay of multiple mouse organs. Mutat. Res. 1998 / 414 (1-3) / 9-14., Grivas, S., Synthetic roots to the food carcinogen 2-amino-3,8-dimethylimidazo(4,5-f)quinozaline (8-MeIQx) and related compounds. Princess Takamatsu Symp. 1995 / 23 / 1-8. (19) De Marini, D.M. et al, Mutation spectrum of cigarette smoke condensate in Salmonella: comparison to mutations in smoking-associated tumors. Carcinogenesis 1995 / 16 (10) / 2535-2542. (20) Sugimura, T. et al, Carcinogenic, Mutagenic, and Comutagenic Aromatic Amines in Human Foods. Natl. Cancer Inst. Monogr. 1981 / 58 / 27-33. (21) Matsumoto, T. et al, Determination of mutagen amino-alpha-carbolines in grilled foods and cigarette smoke condensate. Cancer Lett. 1981 / 12 (1-2) / 105-110. |


